Table 4.
Logistic regression analysis of risk factors for clinical progression in patients with severe COVID-19.
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Variables | OR(95% CI) | p value | OR (95% CI) | p value |
| Age | 1.040 (1.015-1.066) | 0.002 | ||
| Male | 2.416 (1.311-4.452) | 0.005 | ||
| Hypertension | 2.805 (1.536-5.122) | 0.001 | ||
| Coronary heart disease | 2.449 (1.248-4.807) | 0.009 | ||
| Chronic obstructive lung disease | 3.076 (1.400-6.759) | 0.005 | ||
| Respiration rate | 1.116 (1.054-1.181) | <0.001 | ||
| SpO2 | 0.706 (0.649-0.768) | <0.001 | 0.794 (0.726-0.868) | <0.001 |
| Temperature | 1.492 (1.105-2.013) | 0.009 | ||
| NLR | 1.132 (1.089-1.178) | <0.001 | ||
| PLR | 1.002 (1.000-1.003) | 0.045 | ||
| PNI | 0.979 (0.973-0.986) | <0.001 | ||
| SII | 1.000 (1.000-1.001) | <0.001 | ||
| CRP/Alb ratio | 2.176 (1.815-2.610) | <0.001 | 1.888 (1.516-2.352) | <0.001 |
| Aspartate aminotransferase | 1.013 (1.006-1.021) | 0.001 | ||
| Lactate dehydrogenase | 1.007 (1.005-1.009) | <0.001 | ||
| Total bilirubin | 1.083 (1.042-1.124) | <0.001 | ||
| Creatine kinase | 1.003 (1.001-1.004) | <0.001 | ||
| Blood urea nitrogen | 1.055 (1.009-1.104) | 0.019 | ||
| D-dimer | 1.411 (1.286-1.548) | <0.001 | 1.219 (1.085-1.370) | 0.001 |
| Prothrombin time | 1.318 (1.126-1.543) | 0.001 | ||
Abbreviations: SpO2: percutaneous oxygen saturation; NLR: neutrophil-lymphocyte ratio; PLR: platelet-lymphocyte ratio; PNI: prognostic nutritional index; SII: systemic immune-inflammation index; CRP: C-reactive protein; Alb: albumin.