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. 2021 Nov 26;13:710172. doi: 10.3389/fnagi.2021.710172

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Copyright © 2021 Liu, Liu, Cheng, Ge, Hu, Xue, Qi, Xu, Chen, Gao, Rao and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regions that demonstrate between-group differences in the fractional amplitude of low-frequency fluctuation (fALFF). (A) Regions with significant differences across the three groups in fALFF (one-way analysis of covariance (ANCOVA), cluster p < 0.01, cluster size >50 voxels). (B) Regions with significant differences of MCI-highEF group vs. HC in fALFF [two-sample t-test; cluster p < 0.05; cluster size >10 voxels; TFCE-FWE (family-wise error) corrected]. (C) Regions with significant differences of the MCI-lowEF group vs. HC in fALFF (two-sample t-test; cluster p < 0.05; cluster size >10 voxels; TFCE-FWE corrected). MFG.L, left middle frontal gyrus; PosCG.R, right postcentral gyrus; PreCG.R, right precentral gyrus; STG.L, left superior temporal gyrus.