Table 4.
Baseline cardiovascular characteristics by primary solution derived sleep phenotype
| Total | Minimally symptomatic | Excessive sleepiness | Disturbed sleep | P | |
|---|---|---|---|---|---|
| Major comorbidities included in LCA† | |||||
| Hypertension | 54.9 | 52.6 | 57.4 | 56.8 | P = 0.450 |
| Diabetes | 34.1 | 30.4 | 37.7 | 37.5 | P = 0.119 |
| Framingham CVD | 37.6 | 27.7 | 41.6 | 48.8 | P < 0.001 |
| Obstructive lung disease | 8.4 | 9.2 | 12.7 | 5.6 | P = 0.036 |
| Major comorbidities not included in LCA | |||||
| HDL* (mg/dL) | 44.38 (11.56) | 44.76 (12.18) | 43.93 (11.34) | 44.17 (10.83) | P = 0.648 |
| Total cholesterol* (mg/dL) | 206.21 (46.36) | 206.14 (44.82) | 203.87 (45.39) | 207.46 (48.98) | P = 0.758 |
| Triglycerides* (mg/dL) | 173.00 (146.37) | 166.51 (115.59) | 165.96 (94.23) | 184.23 (191.10) | P = 0.272 |
| BMI* (kg/m2) | 33.81 (6.83) | 32.97 (6.43) | 35.04 (7.70) | 34.21 (6.66) | P = 0.003 |
| Current smoker† | 18.9 | 19.1 | 18.2 | 18.8 | P = 0.974 |
| Alcohol use† | 47.4 | 49.8 | 46.8 | 44.5 | P = 0.387 |
| CHD† | 7.7 | 6.3 | 11.5 | 7.9 | P = 0.167 |
| Heart failure† | 3.1 | 3.1 | 3.5 | 2.8 | P = 0.899 |
| Stroke/TIA† | 4.4 | 3.0 | 3.1 | 6.6 | P = 0.040 |
*Means and standard deviations are presented.
†% are presented.
P value: Pearson’s chi square test for continuous variables; Regression-based F test for categorical variables.
HDL, high-density lipoproteins; BMI, body mass index; CHD, coronary heart disease; TIA, transient ischemic attack; LCA, latent class analysis; CVD, cardiovascular disease. This is a 0/1 indicator variable that defines a composite CVD definition based on the Framingham Study criterion (http://www.framinghamheartstudy.org/risk/gencardio.html).