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. 2021 Dec 6;14:467–475. doi: 10.2147/CEG.S269464

Table 2.

Reported Results for FiLaC Studies

Study Median Duration of Follow-Up Mths (Range) Numbers Type of Fistula Secondary Extensions Previous Fistula Surgery Prior Seton Closure of Internal Opening Success
Nordholm-Carstensen et al (2021)12 19 (12–26) 66 High IS – 2 Not reported 22 (32%) 66 (100%) Suture 30 (44.1%)
Low TS – 20
High TS – 41
SS – 5
Wolicki et al (2020)18 41.99 (4–87)* 83 TS/IS – numbers not specified Not reported 28 (33.7%) 65 (78.3%) Z-stitch suture closure 62 (74.7%)
de Bonnechose et al (2020)9 13.6 (6–23) 100 TS low – 8 13 (13%) NS (mean = 2.4 prior operations for entire study population) 83 (100%) None 41 (44.6%)**
TS high – 79
SS - 13
Isik et al (2020)13 48 (6–56) 100 IS – 10 Not reported Not reported Not reported None 62 (62%)
TS low – 28
TS high – 54
SS - 8
Serin et al (2020)10 11 (6–17.6) 35 IS – 21 Not reported 12 (34%) 10 (28.5%) Purse-string closure 15 (42.9%)
TS – 12
SS/ES – 2
Alam et al (2019)20 7.1 (2–22.5) 20 IS – 1 6 (30%) NS (mean - 2.45 prior fistula operations for study population) “Selective” (number not specified) None 11 (55%)
TS low – 3
TS high – 14
SS – 1
ES – 1
De Hous et al (2019)19 9 (4–26) 10 TS – 12 4 (40%) 10 (100%) Not reported Suture 7(70%)
IS – 3 (NB. some patients had multiple fistulas)
Stijns et al (2019)17 10 (7.3)*** 20 IS – 6 0 16 (80%) None 4 (20%)
TS – 14
Marref et al (2019)14 6.3 (4.2–9.3) 69**** IS – 2 22 (32%) 37 (54.4%) 33 (48.5%) None 31 (45.6%)
Low TS – 10
High TS – 45
SS – 11
Terzi et al (2018)22 28 (2–50) 103 Sup – 7 Not reported 34 (33%) 19 (18.4%) None 41 (39.8%)
IS – 56
TS – 29
SS - 11
Lauretta et al (2018)11 11.3 (6–24) 30 TS - 30 0 22 (73.3%) 26 (86.6%) None 10 (33%)
Donmez et al (2017)16 22 (17–26) 27 IS – 14 N Not reported 5 (18.5%) None 24(89%)
TS – 7
SS – 5
ES – 1
Wilhelm et al (2017)15 25.4 (6–60) 117 IS – 8 Not reported 16 (14%) 99 (84.6%) Yes – suture/flap closure 75 (64.1%)
TS – 90
SS – 13
ES – 6
Giamundo et al (2015)21 30 (6–46) 45 IS – 7 0 35 (78%) 24 (53%) None 32 (71%)
Low TS – 7
Mid TS – 19
High TS – 10
SS – 2

Notes: *Mean/SD. **41/92 patients followed up. ***IQR, inter-quartile range. ****1 patient lost to follow-up (so analysis included 68 patients).

Abbreviations: Sup, superficial; IS, intersphincteric; TS, transsphincteric; SS, suprasphincteric; ES, extrasphincteric.