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. 2021 Dec 11;3(1):28–41.e8. doi: 10.1016/j.medj.2021.12.002

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© 2021 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Cohort analysis to compare the incidence rates of symptomatic infection after vaccination with mRNA-1273 versus BNT162b2

(A) The secondary analysis was conducted as a retrospective cohort study. After matching on the basis of demographic and clinical features, we compared the incidence rates of symptomatic infection after full vaccination with mRNA-1273 versus after full vaccination with BNT162b2.

(B) Incidence rate ratios (IRRs) of symptomatic infection for unmatched (top), matched per protocol (PP) (middle), and matched intention-to-treat (ITT) (bottom) analyses. IRRs are shown for days 1–10 after the first dose (baseline estimate), the entire study duration (December 1, 2020 through September 22, 2021), the early epoch (December 1, 2020 through May 31, 2021), and the late epoch (July 1, 2021 through September 22, 2021). The x axis is log-transformed such that, for example, IRRs of 0.5 and 2 are equidistant from the null hypothesis IRR of 1. Error bars represent 95% confidence intervals.