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. 2021 Dec 10;11:23782. doi: 10.1038/s41598-021-03293-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Three-dimensional structures of TPPs (Q9YFR9, Q57676 and Q9YD25) and non-TPPs (Q8ZDC4, Q66A07 and A1AZ52) having the highest (528.74, 527.79 and 525.29, respectively) and lowest (319.67, 331.20 and 340.61, respectively) TPP scores, respectively, where the optimal threshold value is 418.