Table 1:

Examples of interaction between host lipid microdomains and pathogenic fungi

Fungal pathogen	Host cell	Molecular Interaction (pathogen/host)	Functional Response	References
Candida albicans	Monocytes	β- (1,3)- glucan	Phagocytosis	[47]
	Neutrophils	β-(1,6)-side chain-branched β-glucan	Chemotaxis	[45]
		HA1		[48][49][50]
Cryptococcus neoformans	HBMEC1	EVs1	Adhesion and brain invasion	[51]
	AEC1	β- (1,3)- glucan	MIP-2 synthesis1	[52][53]
Pneumocystis jirovecii	Human dendritic cells	β- (1,3)- glucan	Activation of the IL-23/IL-17 axis	[54]
Aspergillus fumigatus	Macrophages	DHN1 melanin	Inhibition of acidification of PL1	[55]
Paracoccidioides brasiliensis	AEC	Not determined	IL-6 and IL-8 secretion	[56]
Histoplasma	AEC	Not determined	IL-6 and IL-8 secretion	[57]
capsulatum	Macrophages	HSP60* and β- (1,3)- glucan*	Phagocytosis and cytokine synthesis	[58][59]

¹HA – Hyaluronic acid, HBMEC - Brain microvascular endothelial cells; EVs - Extracellular Vesicles; DHN - Dihydroxynaphthalene; PL – Phagolysosome; AEC – Alveolar Epithelial Cells, MIP-2 - Macrophage inflammatory protein-2, HSP60 - Heat Shock Protein 60.

^*possible ligands according to literature findings