Table 1:
Baseline characteristics among patients with MRI-detected and MRI-targeted biopsy missed clinically significant cancer
| All patients | GG ≥ 3 on combined biopsy | ||||
|---|---|---|---|---|---|
| N = 2,103 | N | MRI-detected n = 425 | MRI-targeted biopsy missed n = 41 | p-value1 | |
| Age | 64.0 (58.0, 69.0) | 466 | 66.0 (61.0– 71.0) | 65.0 (58.0– 71.0) | 0.3 |
| Race | 466 | 0.7 | |||
| White | 1,653 (79%) | 313 (74%) | 28 (68%) | ||
| Black | 289 (14%) | 72 (17%) | 11 (27%) | ||
| Asian | 75 (3.6%) | 22 (5.2%) | 1 (2.4%) | ||
| Hispanic | 23 (1.1%) | 4 (0.9%) | 0 (0%) | ||
| Other | 39 (1.9%) | 6 (1.4%) | 1 (2.4%) | ||
| Unknown | 24 (1.1%) | 8 (1.9%) | 0 (0%) | ||
| PSA | 466 | <0.001 | |||
| Median (25%–75%) | 6.7 (4.6–10.2) | 10.5 (6.3–17.6) | 7.8 (4.9–11.8) | ||
| Minimum-Maximum | 0.3–231.6 | 1.1–231.6 | 2.6–26.2 | ||
| Clinical Stage (0=no cancer detected) | 466 | 0.1 | |||
| 0 | 791 (38%) | — | — | ||
| T1c | 1,127 (54%) | 319 (75%) | 39 (95%) | ||
| T2a | 155 (7.4%) | 83 (20%) | 2 (4.9%) | ||
| T2b | 13 (0.6%) | 9 (2.1%) | 0 (0%) | ||
| T2c | 16 (0.8%) | 13 (3.1%) | 0 (0%) | ||
| T4 | 1 (<0.1%) | 1 (0.2%) | 0 (0%) | ||
| Prior Biopsy | 466 | 0.2 | |||
| Naive | 436 (21%) | 117 (28%) | 7 (17%) | ||
| Negative | 873 (42%) | 142 (33%) | 13 (32%) | ||
| Positive | 794 (38%) | 166 (39%) | 21 (51%) | ||
| Volume of Prostate on MRI | 451 | <0.001 | |||
| Median (25%–75%) | 51.0 (37.0–71.0) | 42.0 (33.0–58.0) | 50.0 (40.0–61.0) | ||
| Minimum-Maximum | 5.7–420.0 | 13.0–178.0 | 21.7–260.0 | ||
| Number of targets on MRI | 2.0 (1.0– 3.0) | 466 | 3.0 (2.0– 4.0) | 2.0 (1.0– 3.0) | 0.006 |
| GG of MRI-targeted Biopsy | 466 | ||||
| No cancer | 1019 (49%) | — | 9 (22%) | ||
| GG1 | 289 (15%) | — | 8 (20%) | ||
| GG2 | 370 (18%) | — | 24 (59%) | ||
| Highest PI-RADS | 215 | <0.001 | |||
| 2 | 52 (7.0%) | 3 (1.7%) | 2 (4.9%) | ||
| 3 | 89 (12%) | 3 (1.7%) | 5 (12%) | ||
| 4 | 356 (48%) | 48 (28%) | 22 (54%) | ||
| 5 | 249 (33%) | 120 (69%) | 12 (29%) | ||
| Number of cores on FBx | 4.0 (2.0– 6.0) | 466 | 6.0 (4.0– 8.0) | 4.0 (2.0– 6.0) | 0.006 |
| Number of Positive Cores on FBx | 1.0 (0.0– 3.0) | 466 | 4.0 (2.0– 6.0) | 2.0 (1.0– 2.0) | <0.001 |
| Number of Cores on SBx | 12.0 (12.0– 12.0) | 466 | 12.0 (12.0– 12.0) | 12.0 (12.0– 12.0) | 0.032 |
| Number of Positive Cores on SBx | 1.0 (0.0– 3.0) | 466 | 4.0 (1.0– 6.0) | 3.0 (2.0– 5.0) | 0.3 |
| Total # of Cores | 16.0 (15.0– 18.0) | 466 | 18.0 (16.0– 20.0) | 16.0 (14.0– 18.0) | 0.005 |
| Total % Positive Cores | 11.1 (0.0– 31.8) | 466 | 41.4 (26.7– 61.1) | 31.2 (20.0– 43.8) | 0.001 |
1.
Statistical tests performed: Mann Whitney U test; chi-square test of independence