Table 1.

The particle size, polydispersity index, and stability of Iva-Col-NPs prepared in various formulations (n = 3).

Formulation code	Ivacaftor	Colistin	Stabilizers	Drugs-to-stabilizer ratio	DMF (mL)	Water (mL)	Particle size (nm)	PDI	Stability
F1	50	-	-	-	0.75	10	-	-	< 0.1 h
F2	50	50	-	-	0.75	10	185.9 ± 7.2	0.140 ± 0.056	< 2 h
F3	50	50	Poloxamer 188	1:1:1	0.75	10	198.0 ± 5.0	0.174 ± 0.020	< 72 h
F4	50	50	Poloxamer 407	1:1:1	0.75	10	170.6 ± 4.3	0.157 ± 0.053	< 24 h
F5	50	50	Poloxamer 338	1:1:1	0.75	10	251.9 ± 3.1	0.139 ± 0.020	< 1 h
F6	50	50	PVP K90	1:1:1	0.75	10	228.1 ± 1.4	0.130 ± 0.023	< 12 h
F7	50	50	DSPE-PEG	1:1:1	0.75	10	199.3 ± 4.3	0.100 ± 0.076	> 120 h