Table 2.
Summary data of Cannabis Withdrawal Scale.
| Study Visit | Cannabis Withdrawal | Effect Size ǂ | |||
|---|---|---|---|---|---|
| Placebo | Varenicline | Difference | Cohen’s d | Ƞ2p | |
| BL | 39.7 (26.3,53.0) | 31.7 (20.8,42.7) | -- | -- | |
| 4 | 21.4 (14.9,28.0)* | 20.1 (13.2,27.0)* | 1.4 (−8.2,10.9) | 0.06 | -- |
| 5 | 20.9 (14.3,27.6)* | 17.4 (10.5,24.2)* | 3.6 (−6.0,13.1) | 0.15 | -- |
| 6 | 18.8 (12.3,25.4)* | 13.8 (6.8,20.9)* | 5.0 (−4.7,14.6) | 0.21 | -- |
| Overallƚ | 20.4 (14.5,26.2)* | 17.1 (10.9,23.3)* | 3.3 (−5.2,11.8) | 0.14 | 0.001 |
Values are noted as model-based means and associated 95% Confidence intervals adjusted for baseline values of CWS.
ƚ
Overall treatment difference noted as the model based mean treatment effect during weeks 4–6 adjusted for baseline values.
ǂ
Effect sizes are noted as Cohen’s d and are calculated using adjusted model based mean differences and pooled standard deviations. Partial eta squared values are presented for the overall main effect of treatment adjusted for baseline differences.
*
Notes significant within group changes from study baseline levels (p<.05).