Table 3.
Multivariable model of factors associated with the outcome of serum creatinine and/or a healthcare visit during at 30-days, 90-days, and 1-year
| Outpatient serum creatinine AND a healthcare visit | ||||||
| 30-day | 90-day | 1-year | ||||
| Hazard Ratio (95% CI) | P-value | Hazard Ratio (95% CI) | P-value | Hazard Ratio (95% CI) | P-value | |
| Age (per decade) | 0.97 (0.92–1.03) | 0.38 | 0.98 (0.92–1.03) | 0.45 | 0.97 (0.92–1.02) | 0.23 |
| Male sex | 1.14 (0.95–1.39) | 0.16 | 1.16 (0.97–1.39) | 0.099 | 1.17 (0.99–1.39) | 0.072 |
| Discharge eGFR (per 10 mL/min/1.73m2) | 0.91 (0.87–0.95) | <0.001 | 0.91 (0.88–0.95) | <0.001 | 0.92 (0.89–0.95) | <0.001 |
| Charlson comorbidity index (per 1 unit) | 1.03 (1.01–1.06) | 0.014 | 1.04 (1.01–1.06) | 0.004 | 1.04 (1.02–1.07) | 0.001 |
| ICU stay during hospitalization | 1.08 (0.88–1.32) | 0.45 | 1.09 (0.90–1.31) | 0.39 | 1.06 (0.88–1.27) | 0.53 |
| Length of hospitalization (per week) | 1.07 (1.02–1.11) | 0.005 | 1.06 (1.02–1.11) | 0.007 | 1.06 (1.02–1.11) | 0.006 |
| Maximum AKI severity (III vs II) | 1.55 (1.27–1.89) | <0.001 | 1.52 (1.26–1.84) | <0.001 | 1.47 (1.23–1.76) | <0.001 |
| Hospital Readmission (time-dependent) | 1.17 (0.74–1.86) | 0.50 | 1.41 (0.99–2.01) | 0.060 | 1.46 (1.04–2.03) | 0.027 |
| Outpatient serum creatinine | ||||||
| 30-day | 90-day | 1-year | ||||
| Hazard Ratio (95% CI) | P-value | Hazard Ratio (95% CI) | P-value | Hazard Ratio (95% CI) | P-value | |
| Age (per decade) | 0.94 (0.89–1.00) | 0.035 | 0.95 (0.90–1.01) | 0.076 | 0.95 (0.90–1.00) | 0.051 |
| Male sex | 1.17 (0.97–1.40) | 0.096 | 1.21 (1.02–1.43) | 0.032 | 1.22 (1.03–1.44) | 0.019 |
| Discharge eGFR (per 10 mL/min/1.73m2) | 0.89 (0.86–0.93) | <0.001 | 0.90 (0.86–0.93) | <0.001 | 0.90 (0.87–0.93) | <0.001 |
| Charlson comorbidity index (per 1 unit) | 1.04 (1.01–1.07) | 0.002 | 1.04 (1.02–1.07) | 0.001 | 1.04 (1.02–1.07) | <0.001 |
| ICU stay during Hospitalization | 1.24 (1.03–1.50) | 0.022 | 1.25 (1.04–1.49) | 0.015 | 1.23 (1.04–1.46) | 0.015 |
| Length of hospitalization (per week) | 1.06 (1.02–1.10) | 0.007 | 1.06 (1.01–1.10) | 0.010 | 1.05 (1.01–1.10) | 0.016 |
| Maximum AKI severity (III vs II) | 1.61 (1.33–1.94) | <0.001 | 1.60 (1.33–1.92) | <0.001 | 1.59 (1.33–1.90) | <0.001 |
| Hospital Readmission (time-dependent) | 1.12 (0.46–2.73) | 0.80 | 1.64 (0.81–3.33) | 0.17 | 1.80 (0.92–3.51) | 0.084 |
| Healthcare visit | ||||||
| 30-day | 90-day | 1-year | ||||
| Hazard Ratio (95% CI) | P-value | Hazard Ratio (95% CI) | P-value | Hazard Ratio (95% CI) | P-value | |
| Age (per decade) | 1.04 (0.98–1.10) | 0.16 | 1.03 (0.97–1.08) | 0.37 | 1.02 (0.97–1.07) | 0.49 |
| Male sex | 1.03 (0.87–1.24) | 0.71 | 1.02 (0.86–1.21) | 0.81 | 1.04 (0.88–1.23) | 0.63 |
| Discharge eGFR (per 10 mL/min/1.73m2) | 0.97 (0.94–1.01) | 0.15 | 0.98 (0.94–1.01) | 0.18 | 0.98 (0.94–1.01) | 0.14 |
| Charlson comorbidity index (per 1 unit) | 1.03 (1.00–1.06) | 0.023 | 1.04 (1.01–1.06) | 0.003 | 1.04 (1.01–1.06) | 0.003 |
| ICU stay during Hospitalization | 1.16 (0.96–1.39) | 0.12 | 1.13 (0.94–1.35) | 0.18 | 1.11 (0.93–1.33) | 0.23 |
| Length of hospitalization (per week) | 1.06 (1.02–1.10) | 0.002 | 1.06 (1.02–1.10) | 0.003 | 1.06 (1.02–1.10) | 0.003 |
| Maximum AKI severity (III vs II) | 1.21 (1.00–1.46) | 0.051 | 1.22 (1.02–1.46) | 0.032 | 1.19 (0.99–1.42) | 0.057 |
| Hospital Readmission (time-dependent) | 0.78 (0.47–1.29) | 0.33 | 0.98 (0.65–1.47) | 0.91 | 0.97 (0.66–1.44) | 0.89 |
AKI: Acute kidney injury; eGFR: Estimated glomerular filtration rate; ICU: Intensive care unit; CI: Confidence Interval