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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Hypertension. 2021 Nov 23;79(1):139–149. doi: 10.1161/HYPERTENSIONAHA.121.18117

Figure 4.

Figure 4.

A, ABP, rectified/integrated SNA (renal – red, splanchnic - blue, lumbar - green), and RVLM single-unit discharge (rate histogram and raw cell activity) during optogenetic stimulation of OVLT neurons at 5, 10, and 20 Hz using continuous light train (5ms pulse, 15s train). B, Mean±SEM of the change in RVLM discharge and rectified/integrated renal SNA during optogenetic activation of OVLT neurons at 0, 1, 5, 10, and 20 Hz in rats with OVLT mCherry expression versus OVLT-o (without mCherry expression). C and D, Identification of RVLM sympathetic neuron via (C) barosensitive as inflation of an aortic cuff promptly increased ABP and decreased RVLM cell discharge, and (D) RVLM unit was antidromically stimulated from the T2 spinal segment with a constant onset latency (i) and collided by an orthodromic spike (ii). Antidromic examples represent 3 overlapping traces. *P<0.05 vs 0 Hz and lower frequency, ϕ P<0.05 OVLT vs OVLT-x