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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Hypertension. 2021 Nov 5;79(1):79–92. doi: 10.1161/HYPERTENSIONAHA.120.16065

Figure 1. Dll4nAb treatment induces PH in mice.

Figure 1.

(A-B) RVSP (A) and Fulton index (B) in Dll4nAb and control IgG injected mice (n=15). (C-D) Increased muscularization in Dll4nAb injected mice compared with control IgG mice. (C) Representative micrographs of immunofluorescence staining with anti-α-smooth muscle-actin (Acta2) (red) and (D) quantification of muscularized pulmonary arterial vessels. Arrows, muscularized distal pulmonary arterial vessels. Scale bars: 50μm. Nuclei were counterstained by DAPI (blue). Data shown as Mean±SEM; P values were calculated using the Student’s t-test, and *P<0.05; **P<0.01; ***, P<0.001 compared with control group. ns, not significant.