Figure 3. Effect of high glucose on syndecan-3.
(A) mRNA levels (*p<0.05, n=8) and (B) protein expression of syndecan-3 (*p<0.05, n=6–8) decreased significantly in the retinas of diabetic rats. However, no changes were observed in the plasma levels of syndecan-3 in diabetic vs non-diabetic animals (n=5–6). (C) The exposure of RRMEC to high glucose for 6 days also caused a significant decrease in both (D) mRNA (**p<0.01, n=6) and (E) protein levels (**p<0.01, n=6) of syndecan-3. (F) The media levels of syndecan-3 decreased significantly (**p<0.01, n=6) under hyperglycemic conditions. ns = non-significant.