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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Exp Eye Res. 2021 Nov 18;213:108846. doi: 10.1016/j.exer.2021.108846

Figure 4. Effect of high glucose on glypican-1.

Figure 4.

Eight weeks of diabetes caused significant increases in both (A) mRNA levels (*p<0.05, n=6–7) and (B) protein levels (***p<0.001, n=6–8) of glypican-1 in the retinas of diabetic rats. In comparison to those exposed to normal glucose, RRMEC stimulated with high glucose exhibited a significant increase in (D) mRNA levels of glypican-1 (****p<0.0001, n=6); however, protein expression was significantly decreased (****p<0.0001, n=5) (E). No changes were observed in (C) plasma (n=6) or (F) media levels (n=3) of glypican-1 in normal glucose vs hyperglycemic conditions. ns = non-significant.