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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Exp Eye Res. 2021 Nov 18;213:108846. doi: 10.1016/j.exer.2021.108846

Figure 5. Effect of high glucose on CD44.

Figure 5.

(A) A significant increase in mRNA levels of CD44 was observed in the retinas of diabetic animals (**p<0.01, n=6–7). However, retinal protein expression of CD44 was decreased (***p<0.001, n=5) in diabetic rats compared to non-diabetic rats (B). As compared to normal glucose, RRMEC treated with high glucose had a significant increase in both (D) mRNA (*p<0.05, n=6) and (E) protein levels (*p<0.05, n=6) of CD44. In addition, the (C) plasma (n=6) and (F) media levels of CD44 (n=6) were significantly higher (p<0.05) under hyperglycemic conditions, suggesting increased shedding of CD44 in diabetes.