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The average oligomeric state of AM2 wild type (A-E) and drug-resistant S31N (both at 50 μM per monomer) (F-J) with 0 μM (A, F), 19 μM (B, G), 37 μM (C, H), 75 μM (D, I), and 150 μM (E, J) amantadine added. Both AM2 WT and S31N were solubilized in C8E4 at pH 9.
