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. Author manuscript; available in PMC: 2022 Dec 7.
Published in final edited form as: Anal Chem. 2021 Nov 23;93(48):16273–16281. doi: 10.1021/acs.analchem.1c04660

Figure 5.

Figure 5.

Native MS intensities as a function of normalized mass defect versus mass for (all except C) wild type and (C) S31N AM2 in nanodiscs with (A) DMPC, (B) DMPG, (C–F) DPPC lipids. (E) 40 μM and (F) 80 μM amantadine (AMT) were added, and shifts of the tetramer from the dashed reference line indicate 1 or 4 AMT bound. Illustrations to the upper left indicate observed stoichiometries, which are circled and annotated. The cartoon shown above shows a schematic of directly ionizing intact AM2 nanodiscs.