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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Nature. 2021 Nov 10:10.1038/s41586-021-04072-3. doi: 10.1038/s41586-021-04072-3

Figure 3. Ionio conductance increases with size except in human neurons.

Figure 3.

a, Dendritic outside-out patches were pulled from distal dendrites after obtaining whole-cell recordings.

b-c, Dendritic currents. Box plots denote the median and 25–75th percentiles. Sample numbers indicated in parentheses.

b, Kv peak currents (p < 10−8 Kruskal-Wallis, χ 2 = 45 & 5 df).

c, HCN currents (p < 10−16 Kruskal-Wallis, χ 2 = 84 & 5 df).

d, Top, two-photon Z-stack image of distal dendrites. Bottom, distance-dependent median diameter (mouse n = 12, gerbil n = 16, rat n = 10, guinea pig n = 15, rabbit n = 18, human n = 20).

e, Distance-dependent HCN and Kv peak conductance density.

f, Kv currents in somatic outside-out patches. Somatic HCN currents were negligible.

g-i, Allometric relationship on a log-log scale for conductance as a function of neuron size. The lines and shaded error bars represent the fit and 95% confidence interval of an allometric relationship constructed excluding humans.

g, Total (soma and dendrite) Kv peak conductance (p < 10−3, linear regression, F = 193 & 3 df, n = 5).

h, Total HCN conductance (p = 0.011, linear regression, F = 31.6 & 3 df, n = 5).

i, Somatic Kv peak conductance (p < 10−5, linear regression, F = 192 & 7 df, n = 9).