Fig. 1.

Mean ± SD (n = 3) diclofenac data from the small-scale two-stage biphasic system experiments. Percentage of dose (w/w) in solution in the aqueous and decanol layers are represented by the filled and hollow symbols, respectively. Cataflam® and Voltfast® data are represented by black circles and grey triangles, respectively. The dashed line indicates the time of transition from simulated gastric to simulated intestinal conditions. The horizontal dotted line corresponds to the equilibrium concentration of the free acid in dilute HCl (Guhmann et al., 2013) (converted to an equivalent percentage (w/w) of the dose).