Fig. 2.

Mean ± SD (n = 3) diclofenac data from the small-scale two-stage D-P system experiments. (a) Percentage of dose (w/w) in solution in the donor chamber; (b) Percentage of dose (w/w) in solution in the acceptor chamber. The dashed line indicates the time of transition from simulated gastric to simulated intestinal conditions. Cataflam® and Voltfast® data are represented by black circles and grey triangles, respectively. The horizontal dotted line corresponds to the equilibrium concentration of the free acid in dilute HCl (Guhmann et al., 2013) (converted to an equivalent percentage (w/w) of the dose).