Table 4.
Values of pharmacokinetic parameters calculated from in vivo data (n = 27) (Ng et al., 2008) and estimated using PBB modelling (this study) for Norvir® 100 mg tablets.
| In vivo data | Default DLM scalar value & no precipitation | Experimentally derived DLM scalar value (no precipitation) | Experimentally derived PRC value (default DLM scalar value) | Experimentally derived PRC and DLM scalar values | Hypochlorhydric gastric conditions | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PBB model | FD | AAFE | PBB model | FD | AAFE | PBB model | FD | AAFE | PBB model | FD | AAFE | PBB model | FD | AAFE | ||
| Mean AUC (μg.h/mL) | 4.7 | 14.45 | 3.07 | 3.52 | 6.29 | 1.34 | 1.50 | 5.71 | 1.22 | 1.37 | 4.76 | 1.01 | 1.26 | 4.43 | 0.94 | N/A |
| Mean Cmax (mg/L) | 0.60 | 2.07 | 3.44 | 0.74 | 1.24 | 0.68 | 1.13 | 0.56 | 0.93 | 0.52 | 0.87 | |||||
| Mean Tmax (h) | 3.2 | 1.06 | 0.33 | 1.53 | 0.48 | 2.19 | 0.68 | 2.16 | 0.68 | 2.35 | 0.73 | |||||
AAFE: Absolute Average Fold Error; FD: fold difference predicted/observed; PRC = Precipitation Rate Constant; DLM = Diffusion Layer Model.