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. 2021 Nov 12;297(6):101400. doi: 10.1016/j.jbc.2021.101400

Figure 7.

Figure 7

The effect of FXR agonists on expression of ABCB11 and miR-199a-5p in Huh-7 cells.A, overexpression of FXR in Huh-7 cells in the presence of the FXR agonist GW4064 or chenodeoxycholic acid led to marked induction of ABCB11 mRNA and (B) suppression of miR199a-5p mRNA by RT-PCR analysis. C, siRNA knockdown of FXR expression in the presence of the FXR agonist GW4064 or chenodeoxycholic acid suppressed ABCB11 mRNA and (D) increased miR-199a-5p mRNA levels in these cells. Statistical analysis was performed using one-way analysis of variance and Tukey’s correction for multiple comparisons. Each panel represents the mean ± SEM of three separate experiments. ∗ p ≤ 0.05.