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. 2021 Dec 11;26:144. doi: 10.1186/s40001-021-00612-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Hypothetical model for the development of NADRI. ? means a point of divergence. NADRI normoalbuminuric diabetes with renal insufficiency, eGFR estimated glomerular filtration rate, IRS insulin resistance syndrome, IFTA interstitial fibrosis and tubular atrophy, UC underlying conditions, PKC-β protein kinase C-β, AT 1R angiotensin type 1 receptor, RAAS renin-angiotensin-aldosterone system, 8-OHdG 8-hydroxydeoxyguanosine, NL nephron loss, EI endothelial injury