Table 2.

Technical characteristics of single cell genomic amplification methods

	Advantage	Disadvantage	Throughput	Ref
DOP-PCR	Good uniformity	A large amount of sequence information is lost, a bias in amplification, low coverage	Low	[17]
MDA	Simple, high coverage	A bias in amplification, may lead to gene fusion and allele loss.	Higher	[16]
MALBAC	Good uniformity, high accuracy, good fidelity, both fresh and fixed single-cell samples can use	Efficiency is relatively low.	High	[16]
LIANTI	High coverage, good uniformity, low error rate	High false positive rate of C-T base pairs	High	[14]