Table 2.
Measures of depression severity (PHQ-9), cognitive function (PDQ-D), cognitive performance (DSST), and emotional well-being (WHO-5)
| Measures | Baseline (Day 1) | Week 6 | Week 12 |
|---|---|---|---|
| PHQ-9 | |||
| n | 110 | 109 | 111 |
| Mean (SD) | 15.7 (4.8) | 8.9 (5.9) | 7.1 (5.6) |
| Change from baseline | |||
| n | – | 103 | 106 |
| Mean (SD) | – | −6.5 (6.2) | −8.4 (6.2) |
| P value | – | <0.001 | <0.001 |
| PDQ-D | |||
| n | 110 | 106 | 108 |
| Mean (SD) | 40.5 (14.9) | 25.7 (14.9) | 22.2 (15.9) |
| Change from baseline | |||
| n | – | 104 | 106 |
| Mean (SD) | – | −14.8 (13.7) | −18.0 (16.9) |
| P value | – | <0.001 | <0.001 |
| DSST | |||
| n | 113 | 107 | 107 |
| Mean (SD) | 46.7 (11.1) | 50.6 (12.9) | 52.1 (11.7) |
| Change from baseline | |||
| n | – | 105 | 105 |
| Mean (SD) | – | 3.8 (9.8) | 5.2 (8.1) |
| P value | – | <0.001 | <0.001 |
| WHO-5 | |||
| n | 115 | 109 | 109 |
| Mean (SD) | 5.6 (3.48) | 10.8 (5.5) | 12.8 (6.2) |
| Change from baseline | |||
| n | – | 108 | 109 |
| Mean (SD) | – | 5.1 (5.4) | 7.2 (6.6) |
| P value | – | <0.001 | <0.001 |
DSST Digit Symbol Substitution Test, PDQ-D Perceived Deficits Questionnaire-Depression, PHQ-9 Patient Health Questionnaire-Depressive Symptoms, SD standard deviation, WHO-5 World Health Organization-Five Well-Being Index