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. 2021 Dec 11;19:414. doi: 10.1186/s12951-021-01151-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Ce@LTA-NPs neutralized inflammatory factors in vivo and in vitro. A BET analysis for Ce@LTA-NPs. B Co-localization analysis of inflammatory factors and Ce@LTA-NPs in macrophages exposed to LPS. The scale bar is 50 μm. C Western blot analysis of the expression levels of TNF-α and IL-6 in culture medium from LPS stimulated macrophages treated with 50 μg/mL Ce@LTA-NPs. The data are expressed as the mean ± SD (n = 3), *p < 0.05, **p < 0.01, Relative expression ratio (%) of TNF-α and IL-6 was determined by calculating the expression level of TNF-α and IL-6 in group to the expression level of TNF-α and IL-6 in LPS treated group. D Immunofluorescence assay of the expression of TNF-α and IL-6 in diabetic wound treated with F127 hydrogel, F127/CS hydrogel and Ce@LTA-NPs-F127/CS hydrogel. The scale bar is 50 μm