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. 2021 Dec 11;19:414. doi: 10.1186/s12951-021-01151-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 9 — Healing process and histological evaluation of diabetic wound promoted by Ce@LTA-NPs-F127/CS hydrogels dressing. The untreated wound in the normal rat was set as sham group. The untreated wound in a type 1 diabetic rat was set as model group. A Design chart of animal experiment. B Representative images and wound healing rate of full-thickness skin defect in a type 1 diabetic rat model treated with F127 hydrogels, F127/CS hydrogels, Ce@LTA-NPs-F127/CS hydrogels after operation. These data are represented as the means ± SD (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001. C Traces of the wound closure during 14 days for each treatment. D Representative H&E staining images of wound sections treated with F127 hydrogels, F127/CS hydrogels, Ce@LTA-NPs-F127/CS hydrogels at 7th day and 14th day after operation. The scale bar is 100 μm. E Immunohistochemistry assay of CD31 expression in diabetic wound sites treated with F127 hydrogels, F127/CS hydrogels, Ce@LTA-NPs-F127/CS hydrogels at 7th day. Vascular endothelial cell (CD31) and cell nucleus were stained brown and blue. Neovascularization was identified by positive CD31 staining (brown). The scale bar is 50 μm. F Masson’s trichrome staining of wound sections treated with F127 hydrogels, F127/CS hydrogels, Ce@LTA-NPs-F127/CS hydrogels at 14th day after operation. The scale bar is 100 μm