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. 2021 Dec 11;165:101–108. doi: 10.1016/j.amjcard.2021.10.050

Table 2.

Unadjusted ecological association of a county's sociodemographic characteristics with COVID-19–confirmed case rate

Impact factor Direct (county-own) effect
Indirect (spillover) effect
per 1% rate increase Marginal effect (95% CI) p value Marginal effect (95% CI) p value
All CVD drugs use +0.016 (0.007 to 0.026) 0.001 −0.98 (−1.45 to −0.50) <0.0001
 Births in 2019 +0.45 (0.36 to 0.55) <0.0001 −7.09 (−9.05 to −5.14) <0.0001
 Deaths in 2019 −0.08 (−0.16 to −0.005) 0.037 −0.41 (−1.26 to 0.43) 0.337
 GQ Population 2019 +0.02 (0.002 to 0.03) 0.027 0.24 (−0.34 to 0.81) 0.424
 Poverty +0.01 (0.009 to 0.015) <0.0001 −0.05 (−0.10 to −0.013) 0.01
 Median HH income −0.001 (−0.002 to −0.01) 0.004 −0.17 (−0.90 to 0.57) 0.658
 Poor/fair health +2.84 (2.43 to 3.25) <0.0001 −21.44 (−31.34 to −11.54) <0.0001
 Smoking +2.83 (2.30 to 3.36) <0.0001 −77.0 (−130.5 to −23.6) 0.005
 Obesity +1.04 (0.75 to 1.34) <0.0001 −7.02 (−16.40 to 2.35) 0.142
 Physical inactivity +0.88 (0.59 to 1.16) <0.0001 +0.36 (−5.05 to 5.76) 0.897
 Drinking +0.21 (−0.51 to 0.93) 0.573 −1.29 (−8.71 to 6.14) 0.734
 Uninsured (all) +1.07 (0.55 to 1.59) <0.0001 +2.52 (−1.04 to 6.08) 0.165
 Some college −0.67 (−0.82 to −0.52) <0.0001 +2.58 (0.99 to 4.17) 0.001
 Air pollution index +0.07 (0.06 to 0.09) <0.0001 −1.22 (−1.75 to −0.69) <0.0001
 HH with high cost +0.01 (−0.50 to 0.51) 0.984 −34.2 (−41.5 to −26.9) <0.0001
 Food insecurity +0.18 (−0.31 to 0.67) 0.474 −8.48 (−14.68 to −2.64) 0.005
 Insufficient sleep +2.61 (2.06 to 3.17) <0.0001 −47.5 (−65.9 to −29.2) <0.0001
 Population age <18 +2.45 (1.89 to 3.02) <0.0001 +18.05 (16.67 to 19.43) <0.0001
 Population age >65 −2.38 (−2.76 to −2.00) <0.0001 +13.56 (9.07 to 18.04) <0.0001
 Non-Hispanic Black +0.49 (0.38 to 0.60) <0.0001 −2.73 (−3.94 to −1.51) <0.0001
 Native Americans +0.70 (0.48 to 0.92) <0.0001 +31.3 (26.7 to 35.6) <0.0001
 Asians −0.26 (−1.25 to 0.73) 0.602 −9.18 (−25.5 to 7.1) 0.270
 Pacific Islanders −8.1 (−15.7 to −0.6) 0.034 −369.1 (−656.2 to −81.9) 0.012
 Hispanics +1.09 (0.93 to 1.25) <0.0001 −4.6 (−6.8 to −2.3) <0.0001
 Non-Hispanic White −0.71 (−0.82 to −0.61) <0.0001 +1.34 (0.47 to 2.21) 0.003
 Female −2.31 (−3.02 to −1.61) <0.0001 +32.6 (25.9 to 39.2) <0.0001
 CVD hospitalizations +0.004 (0.003 to 0.006) <0.0001 −0.09 (−0.11 to −0.06) <0.0001
 CVD death +0.001 (0.0008 to 0.002) <0.0001 −0.01 (−0.018 to −0.003) 0.006
 HF hospitalizations +0.01 (0.009 to 0.014) <0.0001 −0.17 (−0.21 to −0.14) <0.0001
 HF death +0.0009 (0.0003 to 0.0015) 0.005 +0.001 (−0.008 to 0.010) 0.830
 CHD hospitalizations +0.013 (0.007 to 0.018) <0.0001 −0.39 (−0.59 to −0.19) <0.0001
 CHD death +0.001 (0.0009 to 0.002) <0.0001 −0.01 (−0.02 to −0.0009) 0.031
 Diabetes mellitus +0.01 (0.009 to 0.02) <0.0001 −0.15 (−0.27 to −0.04) 0.010

CHD = coronary heart disease; CI = confidence interval; CVD = cardiovascular disease; HF = heart failure; HH = household.

Statistically significant findings (p<0.05) are highlighted by Bold.