Fig. 1.
a Predicted Cmin for 400 mg and 8 mg/kg dosing using the reference model. b Predicted AUC∞ for 400 mg and 8 mg/kg dosing using the reference model. c Predicted Cmin for 400 mg and 8 mg/kg dosing using the reference model with fourfold inflation of interindividual variability. d Predicted AUC∞ for 400 mg and 8 mg/kg dosing using the reference model with fourfold inflation of interindividual variability. e Predicted Cmin for 600 mg and 8 mg/kg dosing using the reference model. f Predicted AUC∞ for 600 mg and 8 mg/kg dosing using the reference model. g Predicted Cmin for weight-banded fixed dosing and 8 mg/kg dosing using the reference model. h Predicted AUC∞ for weight-banded fixed dosing and 8 mg/kg dosing using the reference model. Cmin minimum concentration, AUC∞ area under the concentration-time curve from time zero to infinity, IQR interquartile range, WT weight