Table 2.

Comparison of DTI-Voodoo with state of the art DTI prediction methods on the Yamanishi dataset; we evaluated the original and the protein-based split in a cross-validation

Approach	Original	Original scheme	Protein split
	Splitting scheme	Macro AUC	Macro AUC	Micro AUCp
Naive predictor	Drugs	0.85	–	–
DTINet	DP pairs	0.91	0.74	0.67
DTIGEMS+	DP pairs	0.93	0.72	0.68
DTI-CDF	Proteins	0.85	0.85	0.79
DTI-Voodoo	Proteins	0.84	0.84	0.84