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Measures of arterial oxygen saturation (SaO2, A) and content (CaO2, B), arterial partial pressure of oxygen (PaO2, C) and carbon dioxide (PaCO2, D), and calculated venous oxygen content (CvO2, E) and arterial/venous oxygen difference (a-vO2 diff, F) during maximal hypoxic (FIO2 = 0.125) exercise before (Day 1, black triangles) and after (Day 15, gray triangles) 14 days of 900 mg daily oral voxelotor administration. *Significantly different to Day 1.
