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. 2021 Jan 18;32(1-2):113–127. doi: 10.1089/hum.2020.127

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Copyright 2021, by Mary Ann Liebert, Inc., publishers

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Figure 1. — Long-term immune restoration in T cell immunity and in situ transduction of BM CD34⁺ HSPCs. (A) Kinetics of gene marking based on fluorophore expression in PB lymphocytes from H867 treated with FV-PGK-mCherry-γC. Lymphocyte population was defined based on forward and side scatter. (B) Kinetics of CD3⁺ cell reconstitution (based on CD3⁺ cells per microliter of blood) in H867. (C) TRECs in PB of H867 (D) colony forming potential of BM CD34⁺ HSPCs in comparison with healthy dog 3.5 years postviral vector injection. (E) Colony forming potential of mCherry⁺ HSPCs, which shows transduction of stem cells by FV vector. Scatter was defined based on forward scatter (FSC) and side scatter (SSC) profile. HSPCs were defined as CD45⁺CD34⁺ cells from BM. BM, bone marrow; FSC, forward scatter; FV, foamy viral; FV-PGK-mCherry-γC, FV expressing mCherry and γC under human phosphoglycerate kinase promoter; HSPC, hematopoietic stem and progenitor cell; PB, peripheral blood; SSC, side scatter; TREC, T cell receptor excision circle.