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. 2021 Jan 18;32(1-2):113–127. doi: 10.1089/hum.2020.127

Figure 5.

Figure 5.

ISA shows polyclonal diversity in cocal-LV-treated dogs. Clonal diversity in mobilized canines H983 (left) and H985 (right) at the indicated time points post-treatment with G-CSF/AMD3100 mobilization and vector cocal-LV-hPGK-EGFP-γC. In the dog H983, a comparative analysis was done on flow-sorted CD3+T cells and WBC on day 273 DPT. In all graphs, unique IS is plotted based on the number of times the IS was sequenced and normalized to the percentage of total IS captured at each time point for each animal. Each unique IS appearing at a frequency >1% in each sample is represented by a colored ribbon. The gray portion of the graph depicts all retroviral integration sites with a frequency <1% at each time point. Numbers on top of the graph represents unique integrations at each time point depicted in the bottom of chart. DPT, day post-treatment; ISA, integration-site analysis.