. 2021 Dec 11;229:114046. doi: 10.1016/j.ejmech.2021.114046

Table 3.

Inhibitory potency against SARS-CoV-2 3CL^pro. Optimization of R³.

Entry	Cmpd	R⁴	Inhibition (%)^a	IC₅₀ (μM)
1	11c	cHex	22 ± 8	nd^b
2	11d	cHex	18 ± 8	nd^b
3	11e	cHex	<5	nd^b
4	11f	cHex	19 ± 8	nd^b
5	11g	cHex	38 ± 8	nd^b
6	11h	cHex	<5	nd^b
7	11i	cHex	24 ± 8	nd^b
8	8c	tBu	24 ± 8	nd^b
9	16d	cHex	22 ± 11	nd^b
10	16e	cHex	>95	0.84 ± 0.30
11	16f	cHex	>95	0.98 ± 0.35
12	13e	cHex	>95	5.0 ± 2.3
13	13f	cHex	80 ± 10	nd^b,c
14	13g	cHex	54 ± 15	nd^b
15	13h	cHex	57 ± 6	nd^b
16	13i	cHex	10 ± 10	nd^b
17	13j	cHex	19 ± 5	nd^b