Table 3.

Advantages and disadvantages of telephone neurocognitive assessment in research

	Patient perspective	Study perspective
Advantages	- Eliminates costs and time related to travel -May reduce caregiver burden related to travel for testing - Provides a familiar testing environment -Reduces anxiety regarding study visit (e.g., being late, finding room)	- May increase willingness to participate in protocol. -May allow inclusion of individuals who would otherwise be unable to attend (e.g., disabled, living far, limited transport options…), broadening the study sample and enhancing external validity of study results. -Mitigates data loss when participant is unable to attend visit physically (e.g., COVID-19 pandemic)
Disadvantages	- Coordination with study personnel requiring multiple phone calls - No visual clues (especially for those with hearing impairment) -No research staff available in person to help with testing materials, potentially anxiogenic -Possible distractions, e.g., other household members, noise	- Time-consuming Logistics (scheduling phone call, sending material to and from participant’s house, etc.) - Costs of mailing via secure courier - Inability to control testing environment (noise, etc.) - Inability to ensure participant follows study procedures (opening envelope prematurely, caregiver help, etc.)