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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Adv Drug Deliv Rev. 2021 Oct 26;179:114021. doi: 10.1016/j.addr.2021.114021

Figure 6. Oral nanomedicine for improving the intestinal barrier functions.

Figure 6.

a, Self-assembly procedure of single-chain CD98 antibody-functionalized siRNA-loaded NPs. b, Specificity of scCD98-functionalized FITC-siRNA–loaded NPs (green) against in vitro colonic epithelial cells (Colon-26 cells; top), macrophages (RAW 267.4; bottom). c-d, In vivo therapeutic efficacy of siCD98 NPs as measured by body weight changes (c), CD98 mRNA levels (d; left), and TNF-alpha mRNA levels (d; right) in the colon of DSS-induced colitis mice. Reproduced with permission from [204].