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Solubility studies in gastric simulated fluids.
| Material | FaSSGF | FeSSIF | FaSSIF |
|---|---|---|---|
| Berberine (mg/mL) | |||
| BBR-PP | 0.603 | 0.329 | 0.365 |
| Berberine extract | 0.188 | 0.129 | 0.149 |
Solubility studies were performed in FaSSGF (fasted-state simulated gastric fluid) at pH 1.6; FaSSIF (fasted-state simulated intestinal fluid) at pH 6.5, or FeSSIF (fed-state simulated intestinal fluid) at pH 5.0.
