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Specificity of the SSA ligands toward the SSTR receptors. Depicted are in vitro affinity profiles (50% inhibitory concentration (IC50) in nM ± standard[52]
| SSTR1 | SSTR2 | SSTR3 | SSTR4 | SSTR5 | |
|---|---|---|---|---|---|
| 68 Ga-DOTATATE | > 10,000 | 0.2 ± 0.04 | > 1000 | 300 ± 140 | 377 ± 18 |
| 68 Ga-DOTA-TOC | > 10,000 | 2.5 ± 0.5 | 613 ± 140 | > 1000 | 73 ± 12 |
| 68 Ga-DOTA-NOC | > 10,000 | 1.9 ± 0.4 | 40 ± 5.8 | 260 ± 74 | 7.2 ± 1.6 |
