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. Author manuscript; available in PMC: 2023 Oct 1.
Published in final edited form as: Semin Cancer Biol. 2021 Jun 12;85:43–51. doi: 10.1016/j.semcancer.2021.06.012

Figure 1. Schematic diagram of domain structure of human NEDD4-subfamily HECT E3 ubiquitin ligases.

Figure 1.

C2, calcium-binding domain; WW, tryptophan - tryptophan (WW) domain; HECT, homologous to the E6-AP carboxyl terminus (HECT) domain. NEDD4, neuronal precursor cell-expressed developmentally downregulated 4; NEDD4L, NEDD4 like E3 ubiquitin protein ligase; ITCH, itchy E3 ubiquitin protein ligase; WWP1, WW domain containing E3 ubiquitin protein ligase 1; WWP2, WV, domain containing E3 ubiquitin protein ligase 2; SMURF1, SMAD specific E3 ubiquitin protein ligase 1; SMURF2, SMAD specific E3 ubiquitin protein ligase 2; HUWE1, HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1; HUWE2, HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 2.