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Kinetic parameters of Tet(X2), Tet(X4), and enzymes carrying the L282S or V329M substitutions on tigecycline
| Protein | kcat (S−1) | KM (μM) | kcat/KM (M−1 S−1) |
|---|---|---|---|
| Tet(X2) | 1.04±0.01 | 4.45±0.13 | 2.33×105 |
| Tet(X4) | 2.03±0.03 | 1.80±0.09 | 1.13×106 |
| L282S | 1.36±0.05 | 3.96±0.38 | 3.43×105 |
| V329M | 3.65±0.10 | 4.81±0.32 | 7.59×105 |
