Table 1.

The functions of m6A methyltransferases in OC

Writer	Expression	Function	Mechanism	Model	Ref.
METTL3	Up	Promotion	METTL3 methylates pri-miR-126-5p to promote miR-126-5p maturation, leading to the activation of PTEN-mediated PI3K/Akt/mTOR pathway	In vitro; in vivo	[36]
METTL3	Up	Promotion	METTL3 increases m6A levels of lncRNA RHPN1-AS1 and contributes to its stability	In vitro	[35]
METTL3	Up	Promotion	METTL3 promotes the translation of AXL catalytic-independently	In vitro; in vivo	[37]
METTL3	Up	Promotion	Independently of METTl14 and WTAP, METTL3 enhances m6A modification in the mRNA of oncogenes in OC, including AXL, CSF-1, EIF3C and FZD10	In vitro	[76]
METTL3	Up	Promotion	METTL3 knockdown downregulates p-AKT and the downstream effector Cyclin D1	In vitro	[83]