Table 3.

The functions of m6A RNA binding proteins in OC

Reader	Expression	Function	Mechanism	Model	Ref.
IGF2BP1	Unknown	Promotion	In a 3′UTR- and m6A-dependent manner, IGF2BP1 promotes SRF expression to augment SRF-dependent transcription	In vitro	[81]
YTHDF1	Unknown	Promotion	YTHDF1 interacts with m6A-modified TRIM29 to promote TRIM29 expression, contributing to CSC features in cisplatin-resistant OC cells	In vitro	[82]
YTHDF1	Up	Promotion	In an m6A-dependent manner, YTHDF1 binds to m6A-modified EIF3C mRNA and augments EIF3C translation	In vitro; in vivo	[40]
YTHDF2	Up	Promotion	YTHDF2, degraded by FBW7, can recognize m6A-modifed BMF mRNA and accelerate decay of the latter	In vitro; in vivo	[80]
YTHDF2	Up	Promotion	YTHDF2, repressed by miR-145, promotes OC progression by decreasing global mRNA m6A levels	In vitro	[112]