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. 2016 Apr 26;2016(4):CD009484. doi: 10.1002/14651858.CD009484.pub2

Mace 2014.

Trial name or title Trial of use of vapocoolant spray to decrease the pain of peripheral IV line placement in adults
Methods Prospective randomized placebo‐controlled trial
Participants Adults > 21years undergoing peripheral IV at a large urban tertiary care hospital ED
112 participants: "demographics and vital signs were not significantly different between the two groups"
Mean age placebo group 48 vs 54 in vapocoolant group
Male placebo 43% vs vapocoolant 40%
Caucasian placebo 40% vs vapocoolant 42%
African American placebo 60% vs vapocoolant 58%
Interventions Intervention group vapocoolant spray (1,1,1,3,3, pentafluoropropane and 1,1,1,2 tetrafluoropropane, Gabauer Pain‐Ease); n = 78
Placebo normal saline spray n = 77
Outcomes Pain measured on a 10‐point scale at 2 points
  • Post spray

  • Post spray and venipuncture. Skin checklist and adverse events self reported

Starting date  
Contact information Sahron Mace, Cleveland
Notes Aims to collect data on 300 participants in total