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. 2021 Nov 18;62:100150. doi: 10.1016/j.jlr.2021.100150

Fig. 2.

Fig. 2

Lower plasma LDL-C in hypercholesterolemic ANGPTL4-deficient mice. A: Schematic description of the study. At 10–15 weeks of age, 18 female ANGPTL4-deficient mice on an APOE3Leiden background and 18 female control APOE3Leiden mice were fed a Western-type diet rich in cholesterol (0.4%) and sunflower oil (33 energy%) for 31 weeks. B: Plasma triglycerides and plasma cholesterol in tail bleeds. C: FPLC-based lipoprotein profiling on pooled plasma collected at the final bleed. D: Serum-amyloid A levels in plasma collected at the final bleed. The error bars are SEM. N = 15–18 per group. Asterisk indicates significantly different from control mice according to Student’s t test (∗P < 0.05, ∗∗∗P < 0.001). ANGPTL, angiopoietin-like protein.