Fig. 3. The maze of NAFLD-interactions and cross-talk among multiple factors leading to hepatic steatosis. Hepatic steatosis itself can give rise to IR.

NAFLD, nonalcoholic fatty liver disease; SREBP 1C, Sterol Regulatory Element Binding Protein 1C; PNPLA 3, Patatin Like Phospholipase Domain Containing Protein-3; TM6SF2, Transmembrane 6 Superfamily Member 2; SNP, Single Nucleotide Polymorphism; DAG, Diacyl Glycerol; TAG, Triacyl Glycerol; VLDL, Very Low-Density Lipoprotein; FXR, Farnesoid X Receptor; TGR5, Takeda G-Protein Receptor 5; NF-ĸB, Nuclear Factor Kappa B; SBA, Secondary Bile Acids; TMAO, Trimethylamine Oxide; PKCє, Protein Kinase C-epsilon isoform.