Table 5.

Clinical signs in patients without PTH1R variants

Patient ID	Age and dentition	1. permanent molars are most frequently affected	2. teeth distal to a PFE-affected molar are also affected	3. supracrestal presentation (eruption pathway completely clear)	4. there is a reduction of vertical growth of the alveolar bone in the affected regions	5. a lateral open bite is present in the affected regions	6. deciduous infraoccluded in mixed dentition	7. asymmetry due to bilaterally unbalanced eruption of the teeth	8. affected individual presents with a bi-lateral affection of PFE	9. affected molars are located in the basal bone of the jaws	10. affected molars show dilacerated roots
39	5,3 mix						x	x
40	6,1 mix						x	x
41	8 mix						x	x
42	13 perm	x						x
62	13 mix
44	10,5 mix						x	x
45	15 perm	x		x	x			x
52	13 mix						x	x
50	6,3 mix						x	x
55	8 mix						x		x
71*	19 perm	x	x	x	x	x		x		x
64	14 mix						x	x
65	8,8 mix						x		x
36	13 perm	x		x				x
31	14 perm	x		x				x
35	14 perm	x		x				x
51	13 perm	x		x		x		x

The hallmark signs (key PFE traits) are italics and listed first, from 1 to 6

Patients marked by * showed at least 5 hallmark signs