Table 2.
Cardiovascular Events According to Transplant Status Among Patients with End-Stage Renal Disease Due to Lupus Nephritis
| Follow-Up (Person Years) | Events, n | Incidence Rate* (95% CI) | Unadjusted HR (95% CI) | Fully-Adjusted HR† (95% CI) | |
|---|---|---|---|---|---|
| Overall | 20900 | 119 | 5.7 (4.7, 6.7) | ||
| Transplanted | 9054 | 19 | 2.1 (1.2, 3.0) | 0.31 (0.19, 0.51) | 0.31 (0.18, 0.53) |
| Not Transplanted | 11846 | 100 | 8.4 (6.8, 10.1) | 1.0 | 1.0 |
| Age at ESRD Onset | |||||
| < 40 Years | 13244 | 60 | 4.5 (3.4, 5.7) | ||
| Transplanted | - | - | 1.5 (0.5, 2.5) | 0.27 (0.13, 0.54) | 0.27 (0.13, 0.56) |
| Not Transplanted | - | - | 7.0 (5.1, 8.9) | 1.0 | 1.0 |
| ≥ 40 Years | 7683 | 59 | 7.7 (5.7, 9.6) | ||
| Transplanted | - | - | 3.2 (1.2, 5.1) | 0.38 (0.19, 0.76) | 0.37 (0.17, 0.78) |
| Not Transplanted | - | - | 10.8 (7.8, 13.8) | 1.0 | 1.0 |
| Sex | |||||
| Female | 17139 | 93 | 5.4 (4.3, 6.5) | ||
| Transplanted | 7400 | 13 | 1.8 (0.8, 2.7) | 0.27 (0.15, 0.48) | 0.28 (0.15, 0.52) |
| Not Transplanted | 9739 | 80 | 8.2 (6.4, 10.0) | 1.0 | 1.0 |
| Race/Ethnicity | |||||
| African American | 10255 | 63 | 6.1 (4.6, 7.7) | ||
| Transplanted | 4020 | 14 | 3.5 (1.7, 5.3) | 0.57 (0.31, 1.05) | 0.59 (0.31, 1.13) |
| Not Transplanted | 6235 | 49 | 7.9 (5.7, 10.1) | 1.0 | 1.0 |
| White | 8503 | 48 | 5.6 (4.0, 7.2) | ||
| Transplanted | - | - | 1.0 (0.0, 1.9) | 0.12 (0.04, 0.33) | 0.12 (0.04, 0.32) |
| Not Transplanted | - | - | 10.0 (7.0, 12.9) | 1.0 | 1.0 |
| Donor Type | |||||
| Living donor | 11346 | 100 | 8.8 (7.1, 10.5) | ||
| Transplanted | - | - | 2.0 (0.5, 3.5) | 0.21 (0.09, 0.45) | 0.21 (0.09, 0.51) |
| Not Transplanted | - | - | 11.8 (9.4, 14.2) | 1.0 | 1.0 |
| Deceased Donor | 16223 | 110 | 6.8 (5.5, 8.0) | ||
| Transplanted | 5597 | 12 | 2.1 (0.9, 3.4) | 0.29 (0.16, 0.52) | 0.24 (0.13, 0.45) |
| Not Transplanted | 10625 | 98 | 9.2 (7.4, 11.0) | 1.0 | 1.0 |
HR, hazard ratio; ESRD, end-stage renal disease
Per 1,000 Person-years;
Adjusted for sex, age, race, ethnicity, ESRD-onset year, first ESRD treatment modality, comorbidity score, Organ Procurement and Transplantation Network region, and history of prior organ transplant
Follow-up for the Not Transplanted group begins at the time of initial waitlisting for kidney transplantation and ends at either death, censoring at the time of kidney transplantation, three years after the index date, or the end of the study period (December 31, 2015). Follow-up for the Transplanted group begins at the time of kidney transplantation and ends at either death, three years after the index date, or the end of the study period (December 31, 2015). Person-years and event counts were suppressed to protect privacy and confidentiality and as restricted by the data use agreement for fewer than 10 events.