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. 2021 Dec 13;50(2):295–308. doi: 10.1007/s15010-021-01730-6

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© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2021

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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Fig. 1 — Schematic representation of SARS-CoV-2 structure, virus entry, and replication in host cells. Virus cell entry by endocytosis is a clathrin-dependent route. Baricitinib effect is usually related to the irregularity in AP2-associated protein kinase 1 and inhibiting SARS-CoV-2 cellular entry through the clathrin-dependent pathway. Antiviral function of remdesivir is related to inhibiting the RNA-dependent RNA polymerase (RdRp)