Table 3.
Association between SNPs of VDR variants and breast cancer in our population.
| SNP | Inheritance state | Genotype | Frequency in control group (number/%) | Frequency in BC group (number/%) | OR, 95% CI |
P-value |
|---|---|---|---|---|---|---|
| BsmI | Recessive | AA-AG | 119 (88.2%) | 101 (75.4%) | 1.00 | 0.0062 |
| GG | 16 (11.8%) | 33 (24.6%) | 2.43 (1.26–4.67) | |||
| Dominant | AA | 52 (38.5%) | 42 (31.3%) | 1.00 | 0.22 | |
| AG-GG | 83 (61.5%) | 92 (68.7%) | 1.37 (0.83–2.27) | |||
| Codominant | AA | 52 (38.5%) | 42 (31.3%) | 1.00 | 0.022 | |
| AG | 67 (49.6%) | 59 (44%) | 1.09 (0.64–1.86) | |||
| GG | 16 (11.8%) | 33 (24.6%) | 2.55 (1.24–5.26) | |||
| ApaI | Recessive | AA-AC | 102 (84.3%) | 113 (81.3%) | 1.00 | 0.52 |
| CC | 19 (15.7%) | 26 (18.7%) | 1.24 (0.65–2.36) | |||
| Dominant | AA | 53 (43.8%) | 83 (59.7%) | 1.00 | 0.01 | |
| AC-CC | 68 (56.2%) | 56 (40.3%) | 0.53 (0.32–0.86) | |||
| Codominant | AA | 53 (43.8%) | 83 (59.7%) | 1.00 | 0.0038 | |
| AC | 49 (40.5%) | 30 (21.6%) | 0.39 (0.22–0.69) | |||
| CC | 19 (15.7%) | 26 (18.7%) | 0.87 (0.44–1.73) | |||
| FokI | Recessive | TT-CT | 92 (67.2%) | 107 (81.1%) | 1.00 | 0.0089 |
| CC | 45 (32.9%) | 25 (18.9%) | 0.48 (0.27–0.84) | |||
| Dominant | TT | 49 (35.8%) | 100 (75.8%) | 1.00 | <0.0001 | |
| CT-CC | 88 (64.2%) | 32 (24.2%) | 0.18 (0.10–0.30) | |||
| Codominant | TT | 49 (35.8%) | 100 (75.8%) | 1.00 | <0.0001 | |
| CT | 43 (31.4%) | 7 (5.3%) | 0.08 (0.03–0.19) | |||
| CC | 45 (32.9%) | 25 (18.9%) | 0.27 (0.15–0.49) | |||
| TaqI | Recessive | TT-TC | 101 (87.1%) | 116 (87.9%) | 1.00 | 0.85 |
| CC | 15 (12.9%) | 16 (12.1%) | 0.93 (0.44–1.97) | |||
| Dominant | TT | 35 (30.2%) | 55 (41.7%) | 1.00 | 0.06 | |
| TC-CC | 81 (69.8%) | 77 (58.3%) | 0.60 (0.36–1.02) | |||
| Codominant | TT | 35 (30.2%) | 55 (41.7%) | 1.00 | 0.16 | |
| TC | 66 (56.9%) | 61 (46.2%) | 0.59 (0.34–1.02) | |||
| CC | 15 (12.9%) | 16 (12.1%) | 0.68 (0.30–1.54) | |||
| Cdx2 | Recessive | GG-AG | 98 (80.3%) | 92 (73.6%) | 1.00 | 0.21 |
| AA | 24 (19.7%) | 33 (26.4%) | 1.46 (0.81–2.66) | |||
| Dominant | GG | 64 (52.5%) | 61 (48.8%) | 1.00 | 0.57 | |
| AG-AA | 58 (47.5%) | 64 (51.2%) | 1.16 (0.70–1.91) | |||
| Codominant | GG | 64 (52.5%) | 61 (48.8%) | 1.00 | 0.45 | |
| AG | 34 (27.9%) | 31 (24.8%) | 0.96 (0.53–1.74) | |||
| AA | 24 (19.7%) | 33 (26.4%) | 1.44 (0.77–2.71) |
BC group: breast cancer group, OR: odds ratio, CI: confidence interval.